The Effect of Polyphenols on Lipid Peroxidation and the Antioxidant System in the Submandular Salivary Glands during Combined Administration of Alcohol and S. typhi Lipopolysaccharide

The purpose of the study was to effect polyphenols (curcumin, epigallocatechin-3-gallate, and quercetin) on indicators lipid peroxidation antioxidant protection in submandibular salivary glands rats with alcohol damage against background lipopolysaccharide-induced systemic inflammatory response. Materials methods. studies were conducted 35 Wistar line weighing 205–220 g, divided into 5 groups seven animals each: 1st group (control) included receiving isotonic sodium chloride solution intragastrically twice a day; 2nd exposed (in dose 24 mg/kg through gavage day) for last 2 weeks during response; 3rd, 4th 5th response, which also received polyphenols, administered intragastrically: curcumin (diferuloylmethane, daily 200 mg/kg), epigallocatechin-3-gallate 40 quercetin respectively. level tissues assessed by formation compounds that react thiobarbituric acid. state increase concentration acid-active products 1.5-hour incubation iron ascorbate buffer solution, as well activity superoxide dismutase. Results discussion. When using under experimental conditions, acid-reactants homogenate before after 59.3 55.7% inferior corresponding results group, when prescribing – 55.7 51.2%, 67.0 61.0%, This accompanied probable dismutase glands. Conclusion. use bioflavonoids (epigallocatechin-3-gallate conditions combined administration 40% ethanol S. typhi lipopolysaccharide significantly limits development glands, increases their potential,